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南开团队揭示MERS-CoV、SARS-CoV主蛋白酶催化机制
来源:欢乐彩_欢乐彩票app免费下载-点击进入>! 发稿时间: 2019-05-21 12:37

  

  南开新闻网讯欢乐彩(记者 吴军辉)近日,经过持续科研攻关,南开大学药学院、药物化学生物学国家重点实验室尚鲁庆副教授课题组揭示了冠状病毒主蛋白酶的催化机制,讨论了冠状病毒MERS-CoV与SARS-CoV主蛋白酶在催化过程中的区别,进而优化了主蛋白酶抑制剂的生物活性。该工作为未来应对冠状病毒的变异奠定了研究基础,旨在助力抗新型冠状病毒药物的研发。介绍该成果的论文发表在美国化学会期刊《ACS Catalysis》上。

  guanzhuangbingdushiyileixingsirimianzhuangdernabingdu,shiyizhirnabingduzhongjuyouzuidajiyinzudebingdu。zi1965nianshoucifenlichurenleizhibingdeguanzhuangbingduyilai,yiyou7zhongguanzhuangbingdubeifaxiankeyidaozhirenleichanshengjibing。qizhong,you4zhongguanzhuangbingduhcov-229e、hcov-nl63、hcov-hku1、hcov-oc43keyidaozhirenleichuxianqingduhuxixitongjibing,zheixiejibingzailinchuangshangzhanhuxidaoganranjibingde10%-30%。qiyudesanzhongguanzhuangbingdusars-cov、mers-covhesars-cov-2(xinxingguanzhuangbingdu)zuoweigaozhibingxingguanzhuangbingdu,qizhisilvgaoda10%-30%。tebieshixinxingguanzhuangbingduyinqidexinguanfeiyan(covid-19),yijikuaidesuduxijuanquanqiu,zhijinyizaochengduoda500wanrenganran,chaoguo30wanhuanzhesiwang。

  zhenduixinguanfeiyanshangwulinchuangtexiaoyaowuyongyizhiliao,tongguoyanjiuguanzhuangbingduguanjianxingdanbaidetongyongjizhi,duiyanfakangbingduyaowujiubiandejiweizhongyao。zaiguanzhuangbingdudeshengminghuodongzhong,qizhudanbaimei(3cyangdanbaimei)nenggouyouxiaodijianqiebingdudedanbaiqianti,jinerchanshengbingdudegongnengxingdanbai,zheiduiguanzhuangbingdudefuzhidengshengminghuodongjiweizhongyao。yinci,zhudanbaimeishikangguanzhuangbingduyaowuyanjiudezhongyaobadian。

  “xianjieduanzhenduigaileidanbaimeideyanjiu,zhuyaojizhongyuqidiwudeteyixingyanjiuheerjuhuadeyanjiu,ranerduiqicuihuajizhiquefaxitongxingdiyanjiu,zhiyuelexiangyingkangbingduyaowudefazhan。yinci,jieshiguanzhuangbingduzhudanbaimeidecuihuajizhi,keyigenghaodishejihefaxianzhudanbaimeiyizhiji,congerjiasukangbingduyaowuyanfa。”shangluqingshuo。

欢乐彩 guanzhuangbingduzhudanbaimeidecuihuajizhiyanjiu

  shangluqingketizuzaihuodemers-covyusars-covzhudanbaimeidejingtijiegoujichushang,goujianmeihuofenxitixi,quedingdanbaimeidecuihuahuoxingzhongxin,suihouzhankaixiangyingdezhutiyanjiu。gaituanduijiehejiegoushengwuxue、danbaitubian、meicufanyingdonglixue、fenzidonglixuemoni、lianghuajisuandengshouduan,yimers-covhesars-covdezhudanbaimeiweiduixiang,duiqishibiejieduanhemeiqiejieduandecuihuajizhijinxingleshenruyanjiu。zaishibiejieduan,gaituanduijieshiledanbaimeides1koudaishibiediwugaodubaoshoudeglndeyuanyin;zaicuihuajieduan,gaituanduiyifangmianyanjiudiwushiruhebeidanbaimeisuoguding,lingyifangmianchanmingdanbaimeizhongcunzaiyigezhongyaodefudianzhongxin。weilegenghaodilijiezheilianggedanbaimeigetidetexing,gaituanduiliyongxiaofenziyizhijitanzhen,jiehejiegoushengwuxue,meixuedengshouduantanjiulemers-covhesars-covzhudanbaimeidecuihuaqubie。

欢乐彩  jiyuyishangduiyucuihuajizhideyanjiu,shangluqingketizuyifangmianyouhualedanbaimeiyizhijidejiegou,youxiaoditigaoleyizhijidehuoxing,weikangbingduyaowudejinyibuyanjiudaxialejianshidejichu;lingyifangmianfaxianleqianzaidebiegouyizhiweidian,weibaxiangdanbaimeidekangbingduyaowuyanfatigonglexindesilu。

欢乐彩  mers-covhesars-cov zhudanbaimeicuihuaguochengzhongdequbieyanjiu

欢乐彩  zhenduixinguanyiqingdesinve,gaiketizuhaijiangxinguanbingdudezhudanbaimeiyuzhiqianbaodaodeguanzhuangbingdudedanbaimeijinxinglexulieduibihefenzidiehe,faxiansuoyanjiudeweidianjunbaoshoudicunzaiyuxinguanbingduhejileiyizhiguanzhuangbingdudezhudanbaimeizhong。“zheibiaoming,huanlecaiyanjiujieshidejizhikenengshiguanzhuangbingduzhudanbaimeidetongyongjizhi,zheiweiyingduimuqianzhengzaisinveyijiweilaixinfadeguanzhuangbingdu,fazhanguangpukangbingduyaowujuyouzhongyaoyiyi。”shangluqingshuo。

  sars-cov-2、sars-cov、mers-covzhudanbaimeidexuliebidui

欢乐彩  julejie,nankaidaxueyaoxueyuanboshiyanjiushengwanghaoweilunwendiyizuozhe,shangluqingfujiaoshou、lidongmeifujiaoshouweigongtongtongxunzuozhe。gaiyanjiugongzuodedaoleguojiazhongdianyanfajihuaxiangmu、guojiazirankexuejijin、tianjinshizirankexuejijinzhichi。

  lunwenlianjie: https://pubs.acs.org/doi/10.1021/acscatal.0c00110

编辑: 张丽

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